The Drosophila melanogaster homologue of the hsp60 gene is encoded by the...
Abstract The hsp60 (heat-shock protein 60) gene family of molecular chaperones has been a subject of study in numerous systems due to its important role in the correct folding of non-native proteins in...
View ArticleA new peroxinectin-like gene preferentially expressed during oogenesis and...
Abstract. Several peroxidase isozymes have been described in Drosophila melanogaster. We describe a peroxinectin-like gene (Dpxt) in D. melanogaster. Peroxinectin is a cell-adhesive hemoperoxidase...
View ArticleThe basal transcription machinery as a target for cancer therapy
AbstractGeneral transcription is required for the growth and survival of all living cells. However, tumor cells require extraordinary levels of transcription, including the transcription of ribosomal...
View ArticledAdd1 and dXNP prevent genome instability by maintaining HP1a localization at...
AbstractTelomeres are important contributors to genome stability, as they prevent linear chromosome end degradation and contribute to the avoidance of telomeric fusions. An important component of the...
View ArticleMolecular effects of dADD1 misexpression in chromatin organization and...
AbstractBackgrounddADD1 and dXNP proteins are the orthologs in Drosophila melanogaster of the ADD and SNF2 domains, respectively, of the ATRX vertebrate’s chromatin remodeler, they suppress position...
View ArticleTrimeric complexes of Antp-TBP with TFIIEβ or Exd modulate transcriptional...
AbstractBackgroundHox proteins finely coordinate antero-posterior axis during embryonic development and through their action specific target genes are expressed at the right time and space to determine...
View ArticleDifferent transcriptional responses by the CRISPRa system in distinct types...
AbstractTranscription factors (TFs) activate gene expression by binding to elements close to promoters or enhancers. Some TFs can bind to heterochromatic regions to initiate gene activation, suggesting...
View ArticleTnaA, a trithorax group protein, modulates wingless expression in different...
Abstractwingless expression is exquisitely regulated by different factors and enhancers in the imaginal wing discs of Drosophila melanogaster in four domains: the dorsal band, the dorso-ventral...
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